News

  • Please note that in July the office hours will be like following:

    Monday, Tuesday, Thursday, Friday 9am-1pm

    Wednesday closed

    Sorry for all inconveniences.

  • Due to the renovation of the room 109, the International Office - (only the staff from the room 109) will be relocated to the room 320 (3rd floor, Institute of Geography)

    The office (room 109) will be closed during its removal on the 5 - 6th July. In urgant cases during those two days please visit our colleagues in the room 36 (ground floor).

    We apologise for any inconvenience.

Combinatorial Chemistry

Program: 
Chemistry
ECTS: 
4
Lecturer: 
dr Alicja Kluczyk; dr Marek Cebrat
Type: 
Optional
Level: 
Elementary
Lecture
Number of hours: 
1h X 15 weeks = 15 hours (1 semester)
Laboratory
Number of hours: 
2h X 15 weeks = 30 hours (1 semester)
Objective: 

Providing students with knowledge of combinatorial chemistry
Presentation of modern methods of design and synthesis of bioactive compounds
Presentation of applications of combinatorial chemistry in medicinal, analytical and organic chemistry, and certain aspects of inorganic chemistry
Acquired Knowledge
Student
• is in possession of an extensive knowledge of main concepts of combinatorial chemistry and diversity of organic compounds
• is in possession of extensive knowledge of experimental methods applicable in the field of combinatorial chemistry
• has knowledge of the procedures used in search for bioactive compounds, novel materials and reagents
Acquired Skills
Student:
• is able to plan the design, synthesis and analysis of combinatorial libraries
• is able to search for information in professional literature, databases as well as other sources
• is able, in an advanced manner, to present research results and literature data in a written form
Social competence
Student:
• understands the need of systematic contact with scientific literature to extend and integrate the acquired information with knowledge of chemistry
• is able to plan and conduct the experiments in cooperation with other students, following the safety procedures

Assessment: 

Lecture: semester paper, written test
Laboratory: preparing and implementing a project, written reports

Contents: 

Lecture: Combinatorial chemistry. Combinatorial libraries. Natural libraries: immune response, proteins, antibiotics, polyketides, phage systems and viruses. Synthetic and virtual libraries.

Combinatorial biosynthesis. General and focused libraries, library design, deconvolution. Chemical diversity, Synthetic and analytical procedures, screening protocols, HTPS. Application of combinatorial libraries in biological and organic chemistry as well as in analytical chemistry and material science.

Development of inhibitors and catalysts. Bioinformatics and data mining.

Laboratory: Classical organic synthesis, solid phase chemistry and polymer-assisted solution synthesis. Design of a library, synthesis, analysis, prediction of physicochemical and biological properties. Evaluation of synthetic methods. Applications of solid phase synthesis: biopolymers and natural products, combinatorial libraries, analytical applications.