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Combinatorial Chemistry

Program: 
Chemistry
ECTS: 
4
Lecturer: 
dr Alicja Kluczyk; dr Marek Cebrat
Type: 
Optional
Level: 
Elementary
Lecture
Number of hours: 
1h X 15 weeks = 15 hours (1 semester)
Laboratory
Number of hours: 
2h X 15 weeks = 30 hours (1 semester)
Objective: 

1. Providing students with knowledge of combinatorial chemistry
2. Presentation of modern methods of design and synthesis of bioactive compounds
3. Presentation of applications of combinatorial chemistry in medicinal, analytical and organic chemistry, and certain aspects of inorganic chemistry

Assessment: 

Lecture: oral exam based on discussion of prepared report; credit – preparation of report on current topics in course subject
Laboratory: evaluation of synthetic project, written report.

Prerequisites: 

Completed (credited) Organic Chemistry course.

Contents: 

Lecture: Combinatorial chemistry. Combinatorial libraries. Natural libraries: immune response, proteins, antibiotics, polyketides, phage systems and viruses. Synthetic and virtual libraries.
Combinatorial biosynthesis. General and focused libraries, library design, deconvolution. Chemical diversity, Synthetic and analytical procedures, screening protocols, HTPS. Application of combinatorial libraries in biological and organic chemistry as well as in analytical chemistry and material science. Development of inhibitors and catalysts. Bioinformatics and data mining.
Laboratory: Classical organic synthesis, solid phase chemistry and polymer-assisted solution synthesis. Design of a library, synthesis, analysis, prediction of physicochemical and biological properties. Evaluation of synthetic methods. Applications of solid phase synthesis