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Bioorganic chemistry with elements of molecular biology

Program: 
Chemistry
ECTS: 
4
Lecturer: 
dr hab. Piotr Stefanowicz
Type: 
Optional
Level: 
Medium
Lecture
Number of hours: 
1h X 15 weeks = 15 hours (1 semester)
Laboratory
Number of hours: 
1h X 15 weeks = 15 hours (1 semester)
Objective: 

Knowledge of foundations and contemporary problems of bioorganic chemistry

Assessment: 

Ways of earning credits for the completion of a course /particular component, methods of assessing academic progress:
1. Lecture: an oral exam.
2. Laboratory: The day-by-day assessment conducted by the instructor during the laboratory work and evaluation of written report on performed experiments.

Contents: 

Lecture (one semester 15 h in total):

I. Molecules of Life

1. Chemical bonds and shape of organic molecules

2. Nucleotides and nucleic acids

3. Amino acids, peptides and proteins

4. Carbohydrates and lipids

5. „Natural Products” – secondary metabolites

II. Biological Activity1. Quantitative aspects of biological activity2. Examples of molecular targets: receptors, ion channels and their ligands3. Molecules interacting with nucleic acids4. Enzyme inhibitors and molecules interacting with proteins involved in cellular adhesion 5. Designing of biologically active compounds

Laboratory (one semester, 15 h,):

Isolation of natural products from biological sources.

1. Chemical and spectroscopic characterization of organic compounds.

2. Chromatographic methods: TLC, gel filtration, HPLC.

3. Peptide chemistry: synthesis and sequence analysis.